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Ultram (Tramadol Hcl) Drug Information: User Reviews, Side Effects, Drug Interactions and Dosage at RxListGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.The molecular weight of tramadol hydrochloride is 299.8.
Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It
is readily soluble in water and ethanol and has a pKa of 9.41. The
n-octanol/water log partition coefficient (logP) is 1.35 at pH 7. ULTRAM
tablets contain 50 mg of tramadol hydrochloride and are white in color.
Inactive ingredients in the tablet are pregelatinized corn starch, modified
starch (corn), hypromellose, lactose, magnesium stearate, microcrystalline
cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate,
titanium dioxide and carnauba wax.ULTRAM was administered to 550 patients during the
double-blind or open-label extension periods in U.S. studies of chronic
nonmalignant pain. Of these patients, 375 were 65 years old or older. Table 2
reports the cumulative incidence rate of adverse reactions by 7, 30 and 90 days
for the most frequent reactions (5% or more by 7 days). The most frequently
reported events were in the central nervous system and gastrointestinal system.
Although the reactions listed in the table are felt to be probably related to
ULTRAM administration, the reported rates also include some events that may
have been due to underlying disease or concomitant medication. The overall
incidence rates of adverse experiences in these trials were similar for ULTRAM
and the active control groups, TYLENOL with Codeine #3 (acetaminophen 300 mg
with codeine phosphate 30 mg), and aspirin 325 mg with codeine phosphate 30 mg,
however, the rates of withdrawals due to adverse events appeared to be higher
in the ULTRAM groups.